Androtec Andrographolide is a diterpene lactone compound extracted from the plant Andrographis paniculata of the Acanthaceae family. It is the effective ingredient of Andrographis paniculata.It is white square prism or flaky crystal, odorless and bitter. The androglafolide dissolves in boiling ethanol, melts slightly into methanol or ethanol, hardly melts in chloroform, and hardly melts into water or ether.

Modern pharmacological studies have shown that in addition to anti-inflammatory effects, andrographolide also has hypoglycemic, anti-senile dementia, antibacterial, liver protection, anti-tumor, anti-viral and other activities, and is widely used in the field of medicine.

Andrographolide is an organic compound, with molecular formula C20H30O5, and white rhombic or flaky crystal. The main effective ingredient of the natural plant Andrographis paniculata has the effect of dispelling heat and detoxicating, diminishing inflammation and relieving pain. It is known as the natural antibiotic medicine. This product is a diterpenoid lactone compound, which is insoluble in water and can only be administered orally.

 

Andrographolide Suppliers

Kintai is committed to producing and providing you with the best Andrographolide. The content of Andrographolide we produce is 98%. If you have other content requirements, please feel free to contact us.

 

 

Product Quality Standard of Andrographolide：

Product name	Andrographolide
Extract source	Andrographis paniculata whole grass or leaves
Extraction Solvent	Ethyl alcohol
Appearance	White powder
Solubility	Dissolve in boiling ethanol, slightly soluble in methanol or ethanol, very slightly soluble in chloroform, and almost insoluble in water or ether.
Identification	TLC , HPLC
Sulphated Ash	NMT 0.5%
Heavy metals	NMT 20 PPM
Loss On Drying	NMT 5.0%
Powder size	80Mesh, NLT90%
Assay of Andrographolide (HPLC test, percent, Standard in House)	Min. 95.0%
Residual Solvents
- N-hexane	NMT 290 PPM
- Methanol	NMT 3000 PPM
- Acetone	NMT 5000 PPM
- Ethyl Acetate	NMT 5000 PPM
- Ethanol	NMT 5000 PPM
Pesticide Residues
- Total DDT (Sum of p,p'-DDD,P,P'-DDE,o,p'-DDT and p,p' -DDT)	NMT 0.05 PPM
- Aldrin, Endrin, Dieldrin	NMT 0.01 PPM
Microbiological Quality (Total viable aerobic count)
- Bacteria, CFU/g, not more than	NMT 103
- Moulds and yeasts, CFU/g, not more than	NMT 102
- E.coli, Salmonella, S. aureus, CFU/g	Absence
Storage	In Tight, Light-resistant and Dry Place. Avoid Direct Sunshine.
Shelf life	24 months

 

 

 

 

3.1 Extract source

Andrographolide is the whole herb extract of Andrographis paniculata (Burm.f) Nees, a 1-year-old herb of the family Acanthaceae. , Elemi, bitter gall grass, golden vanilla, golden ear hook, Indian grass, bitter grass and so on. Medicinal plants have the functions of clearing away heat and detoxification, reducing inflammation, reducing swelling and relieving pain.

Leaf-containing diterpene lactone compounds: andrographolide A (deoxyandrographolide) 0.1% or more, andrographolide B (andrographolide 1.5% or more), andrographolide (neoandrographolide) 0.2% or more; and homoandrographolide, Panein lactone. It also contains andrographene, andrographone, andrographol, β-sitosterol-D-glucoside, etc.
In addition to containing andrographolide, it also contains 5-hydroxyl-7,8,2',3'-tetramethoxyflavone, 5-hydroxyl-7,8,2'-trimethoxyflavone , 5,2'--dihydroxyl--7,8--dimethoxyflavone, apigenin--7,4'--dimethyl ether, α--sitosterol, etc.
The whole plant still contains 14--deoxy--11--oxidized andrographolide, 14--deoxy--11,12--didehydroandrographolide, and according to preliminary analysis, it also contains sterol saponins and sugars and condensed tannins and other phenolic substances.
The callus obtained from leaves, twigs, hypocotyls, roots and germs was cultured and separated to obtain three kinds of sesquiterpene lactone compounds: elemenolide A, B and C.

 

3.2 Chemical and physical properties

CAS Number	5508-58-7	Molecular Weight	350.449
Density	1.2±0.1 g/cm3	Boiling Point	557.3±50.0 °C at 760 mmHg
Molecular Formula	C20H30O5	Melting Point	229-232ºC
Common Name	Andrographolide	Flash Point	195.5±23.6 °C

 

 

 

4.1 Health Benefits

According to the latest pharmacological experiments,Androtec andrographolide has the following effects on health:

✔️ Microbial action of disease resistance agent.

✔️ Antipyretic action.

✔️ Anti-inflammatory effect.

✔️ Antifertility.

✔️ Cholagogic and liver protective effects.

✔️ Antitumor activity.

 

4.2 Application

The main active ingredients of Andrographis paniculata are diterpene lactones, which have anti-inflammatory, antibacterial, and antiviral effects. Among them, andrographolide and dehydroandrographolide have the highest content, and dehydroandrographolide is the most effective one in andrographolide compounds. Drugs made from andrographolide or dehydroandrographolide and their derivatives, such as andrographolide tablets, Chuanhuning injection, Yanhuning injection, etc., have been widely used clinically.

 

 

4.3 Clinical application

(1) Treatment of various infectious diseases;

(2) Treat typhoid fever;

(3) Treat pneumonia and other respiratory inflammation;

(4) Treatment of infantile dyspepsia and bacillary dysentery;

(5) Treatment of neurodermatitis and eczema;

(6) Cure snakebite.

 

 

 

 

 

 

 

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